N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
N-[2-[2-(Dimethylamino)Ethoxy]-4-(1H-Pyrazol-4-yl)Phenyl]-2,3-Dihydro-1,4-Benzodioxin-2-Carboxamide
CAS: 1072959-67-1
Molecular Formula: C22H24N4O4
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide - Names and Identifiers
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide - Physico-chemical Properties
| Molecular Formula | C22H24N4O4 |
| Molar Mass | 408.45 |
| Density | 1.298 |
| Boling Point | 646.9±55.0 °C(Predicted) |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to light brown |
| pKa | 11.90±0.70(Predicted) |
| Storage Condition | Desiccate at RT |
| In vitro study | SR-3677 has an IC 50 of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC 50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677. |
| In vivo study | ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 µM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points. |
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.448 ml | 12.241 ml | 24.483 ml |
| 5 mM | 0.49 ml | 2.448 ml | 4.897 ml |
| 10 mM | 0.245 ml | 1.224 ml | 2.448 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.49 ml |
Last Update：2024-01-02 23:10:35
N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide - Reference Information
| biological activity | SR-3677 is a highly efficient and selective ROCK-II inhibitor with an IC50 value of ~ 3 nM. |
| target | ROCK-II 3 nM (IC 50 ) ROCK-I 56 nM (IC 50 ) |
| in vitro study | SR-3677 has an IC 50 of ~ 3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC 50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane of the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677. |
| in vivo study | ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 m SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70-80% for the 2-5 h time points. |
Last Update：2024-04-10 22:29:15
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Product Name: N-[2-[2-(Dimethylamino)Ethoxy]-4-(1H-Pyrazol-4-yl)Phenyl]-2,3-Dihydro-1,4-Benzodioxin-2-Carboxamide Visit Supplier Webpage Request for quotation
CAS: 1072959-67-1
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1072959-67-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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